UDK: 615.252.349:616.379-008.64

INFLUENCE OF GPR119 RECEPTOR AGONIST ON INSULIN PRODUCTION AND INSULIN RESISTANCE IN INTACT RATS AND RATS WITH EXPERIMENTAL DIABETES MELLITUS

D. V. Kurkin, D. A. Bakulin, E. V. Volotova, I. N. Tyurenkov

Волгоградский государственный медицинский университет, кафедра фармакологии и биофармации ФУВ

Abstract

Hypoglycemic action of ZB-16, a novel GPR119 receptor agonist, is incretin-mediated and involves increased secretion of insulin in response to a glucose load. The administration of ZB-16 reduces glucose tolerance and insulin resistance index in rats with type 2 diabetes mellitus.

Keywords

diabetes, insulin, GPR119, ZB-16, dipiaron, rats.

Contacts

Куркин Денис Владимирович – к. фарм. н., ассистент кафедры фармакологии и биофармации ФУВ, Волгоградский государственный медицинский университет, e-mail: strannik986@mail.ru