UDK: 616.36:577.151]:618.5-06]-092.9

EXPRESSION OF MATRIX METALLOPROTEINASE-9 AND TISSUE INHIBITOR OF MATRIX METALLOPROTEINASES-1 IN THE LIVER IN NEONATAL MICE OF CBA AND C57B1/6 LINES, WHICH UNDERWENT CHRONIC INTRAUTERINE HYPOXIA

S.P. Mozoleva1, A.P. Nadeev1, 2, S.V. Pozdnyakova1, T.A. Ageeva1, P.A. Elyasin1

1ФГБОУ ВО «Новосибирский государственный медицинский университет» Министерства здравоохранения Российской Федерации, кафедра патологической анатомии; 2НИИ экспериментальной и клинической медицины при Федеральном исследовательском центре «Фундаментальная и

Abstract

The aim of the study was to study the expression of matrix metalloproteinase-9 (MMP-9) and its tissue inhibitor 1 (TIMP-1) in hepatocytes and nonparenchymal liver cells in neonatal mice of two opposing lines of CBA and C57B1/6 after chronic intrauterine hypoxia. In The total expression level of MMP-9 and TIMP-1 in hepatocyte cells was more pronounced in CBA mice, in compared with mice of the C57B1/6 line.

Keywords

matrix metalloproteinase-9, tissue inhibitor of matrix metalloproteinases-1, chronic intrauterine hypoxia, liver, newborns, mice of CBA and C57Bl/6 lines.

Contacts

Надеев Александр Петрович – д. м. н., профессор, зав. кафедрой патологической анатомии, Новосибирский государственный медицинский университет, e-mail: nadeevngma@mail.ru