UDK: 577.29:615+615.017:616.079

EVALUATION OF DOSE-DEPENDENT EFFECTS OF 3-FORMYL-SUBSTITUTED DERIVATIVE OF CHROMONE IN CONDITIONS OF MUSCLE DYSFUNCTION

A.V. Voronkov1, D.I. Pozdnyakov1, O.F. Veselova2, .A. Olohova2, V.M. Rukovicina1

1Пятигорский медико-фармацевтический институт, филиал ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации; 2ФГБОУ ВО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-

Abstract

The study presents data reflecting the dose-dependent action of the new 3-formyl-substituted derivative of chromone in the conditions of muscle dysfunction, reproduced in the «treadmill running» test, in comparison with the reference drug – «Metaprot» at a dose of 25 mg/kg. As a result of study, it was found that the studied 3-formyl-substituted derivative of chromone has the most pronounced effect on the activity of skeletal muscle at a dose of 20 mg/kg, which was confirmed by functional and biochemical tests.

Keywords

muscle dysfunction, chromone derivatives, dose-dependent action.

Contacts

Воронков Андрей Владиславович – д. м. н., доцент, заведующий кафедрой фармакологии с курсом клинической фармакологии, ПМФИ-филиала ФГБОУ ВО ВолгГМУ МЗ РФ, email: prohor.77@mail.ru