UDK: 616.379-008.64:616.1

SERUM GLYCOSAMINOGLYCANES AND ANTIBODIES TO THEM AS DIAGNOSTIC MARKERS OF VASCULAR COMPLICATIONS IN PATIENTS WITH DIABETES MELLITUS

E. A. Kameneva, O. A. Zaharina, A. R. Babaeva

Кафедра факультетской терапии ВолГМУ

Abstract

The purpose of the study is to develop laboratory methods of diagnostics of diabetic angiopathy by measuring the level of serum glycosaminoglycanes (GAG) and antibodies to them in the blood of patients with diabetes mellitus. An increased level of serum GAG and of antibodies to them in patients with diabetes mellitus type 1 and 2 was determined in comparison with control group. The extent of laboratory changes depended on the severity of disease and vascular complica-tions. Measurements of the level of serum glycosaminoglycanes (GAG) and antibodies to them can be used as markers of diabetic angiopathy.

Keywords

diabetic angiopathy, glycosaminoglycanes, antibodies, collagen, hyaluronic acid

Contacts

Бабаева Аида Руфатовна – д.м.н., профессор, зав.кафедрой факультетской терапии ВолГМУ, babaeva_ar@volgmed.ru