UDK: 615:547.466.3:618.3-008.6-092.4
E.A. Muzyko, M.V. Kustova, K.V. Suvorin, V.N. Perfilova, I.N. Tyurenkov
ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации
The effect of course intragastric administration of gamma-aminobutyric acid derivatives (GABA) such as succicard 22 mg/kg, salifen 7,5 mg/kg, phenibut 25 mg/kg and comparison of drug pantogam 50 mg on the concentration of malondialdehyde (MDA) and the activity of catalase and superoxide dismutase (SOD) in the plasma of offspring at the age of 8, 14 and 20 months, who was born from rats with experimental preeclampsia (EP), was studied. EP has decreased the activity of antioxidant enzymes and increased concentration of lipid peroxidation products in offspring from females with EP in long periods of ontogenesis (8, 14 and 20 months). The GABA derivatives administration from 40 to 70 days of life to the progeny from rats with EP has decreased MDA level in animals at the age of 8 months treated with salifen, in 14 months – in those receiving succicard and comparison of drug pantogam, in 20 months – pantogam. In addition, the activity of SOD has increased at the age of 14 months in rats, which were treated by succicard, salifen, phenibut, and pantogam, and at 8 and 20 months in those receiving pantogam. An increase in catalase activity was observed at the age of 8 months in the offspring who were treated with phenibut and salifen, at 14 months – who received succicard.
experimental preeclampsia, offspring, GABA derivatives, oxidant and antioxidant status.
Музыко Елена Андреевна – аспирант кафедры фармакологии и фармации ИНМФО, Волгоградский государственный медицинский университет, e-mail: muzyko.elena@mail.ru