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Synthesis and anti-HIV-1 effect of 1-[[2- (phenoxy)ethoxy]methyl] derivatives of uracil

Novikov M.S., Ozerov A.A., Orlova Yu.A., Buckheit R.W.

Лаборатория фармацевтической химии ВНЦ РАМН и Администрации Волгоградской области, Кафедра фармацевтической химии ВолГМУ,* ImQuest BioSciences, Inc. (Мериленд, США)

Abstract

Antiviral activity of new syntetized compounds was studied in vitro using CEM-SS gulture. 1-[[2-4(4- chlorphenoxy)ethoxy]methyl] and 1-[[2-(4-methylphenoxy)ethoxy]-methyl derivatives of 5-brome-6-methyluracyle demonstrate maximum inhibitory on HIV-1 virus comparing with the other ones.

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Contacts

Озеров Александр Александрович – д.х.н., профессор, зав.кафедрой фармацевтической и токсикологической химии, ozerov@vlink.ru