UDK: 616.735.5.002.61:34.49.003

HEMOPOESIS AND FUNCTIONAL CONDITION OF BLOOD LEUKOCYTES DURING INFLAMMATION IN THE BACKGROUND OF LOCAL REMOVAL OF NONPHOCOTATING GRANULOZITES

A.G. Sirak, E.I. Piskareva, M.A. Dolgashova, O.G. Magomedova, A.P. Arutyunova, O.V. Lyubanskaya, E.G. Nemenuschaya, M.O. Didenko, Z.M. Kochkarova

ФГБОУ ВО «Ставропольский государственный медицинский университет» Министерства здравоохранения Российской Федерации, кафедра гистологии

Abstract

The article is devoted to the functional state of blood leukocytes and peculiarities of hematopoiesis during inflammation under experimental conditions against the background of local removal of non-phagocytic granulocytes. The functional status of blood leukocytes obtained from 24 Wistar male rats weighing 180–220 g was judged by the activity of their marker enzymes. Myeloperoxidase (MPO) and acid phosphatase (CF), macrophage monocytes – α-naphthylacetate esterase (α-NAE), lymphocytes – CF and α-NAE served as markers of the functional activity of neutrophils. Found that during inflammation on the background of prior removal of NG from the focus, there is less neutrophil and monocyte entry from the bone marrow into the blood and further into the inflammation focus, changes in the intensity and dynamics of hemopoiesis, and as a result, increased lymphocyte degranulation.

Keywords

inflammation, experiment, non-phagocytic granulocytes, myeloperoxidase, acid phosphatase, α-naphthylacetate esterase.

Contacts

Сирак Алла Григорьевна – д. м. н., профессор, зав. кафедрой гистологии, Ставропольский государственный медицинский университет, e-mail: sergejsirak@yandex.ru