UDK: 615: 611-013.1/.2
E.A. Kuzubova, L.I. Bugaeva, E.B. Lavrova, M.V. Maltsev, V.I. Petrov, T.M. Avilova, N.M. Shherbakova, I.V. Kharlamov
Научно-исследовательский институт фармакологии ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации
In experiments on female rats, the effect of afobazole at doses of 5 mg/kg (group 1) and 100 mg/kg (group 2) on sexual behavior and fertility was studied. It was found that in the structure of sexual behavior in rats of females treated with afobazole with a 2-week course, the duration of sexual activity and the number of lordoses decreased statistically insignificantly and dose-dependently (by 12,5 and 37,5 %, respectively), with a simultaneous tendency to increase the number emotional approaches. In addition, according to the results of fertility studies in female rats, an increase in the pregnancy index by 14,6 % (p > 0,05) was noted in both study groups, and in pregnant women, an increase in fertility, respectively, by 33,7 % (p < 0,05) and 20,4 % (p < 0,05) and a dose-dependent decrease in the total (pre- and post-implantation) fetal death by 26,4 % (p > 0,05) and 54,5 % (p < 0,05). Based on the studies, it was concluded that afobazole had a positive effect on 2-weekly administration to rats of females at doses of 5 mg/kg and 100 mg/kg on fertility processes, with a slight tendency of its deprimative effect on sexual activity.
benzimidazole derivatives, preclinical studies, generative function, sexual behavior, fertility.
Мальцев Михаил Васильевич – к. б. н., доцент кафедры фармакологии и биоинформатики, Волгоградский государственный медицинский университет, e-mail: m_maltsev_biolog@rambler.ru