UDK: 615.212.7:616.831-005-092.4

CEREBROPROTECTIVE ACTIVITY OF NOVEL ADAMANTANE DERIVATIVE OF 2-PYRROLIDONE IN RATS WITH BRAIN ISCHEMIA

N.S. Kovalev 1, D.A. Bakulin 1, D.V. Kurkin 1, M.A. Dubrovina 1, A.S. Tarasov 1, Yu.N. Klimochkin 2, I.M. Tkachenko 2

1 ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации; 2 ФГБОУ ВО «Самарский государственный технический университет»

Abstract

The cerebroprotective effect of novel adamantane derivative of 2-pyrrolidone in rats with brain ischemia was studied. Pathology was modeled by irreversible occlusion of the common carotid arteries. In rats with experimental cerebral ischemia, there was a significant impairment of coordination of movements and sensory-motor functions: it was more difficult for animals to stay on the rotating rod, as well as in the «adhesive removal test» to notice and get rid of the sticker on the volar surface of the forepaws. In the «new object recognition» test, the animals of the control group showed impaired working memory. Course administration of the investigated derivative of 2-pyrrolidone and citicoline contributed to a significant correction of motor and cognitive impairments.

Keywords

adamantane, 2-pyrrolidone, citicoline, cerebral ischemia, neurological deficit, memory.

Contacts

Бакулин Дмитрий Александрович – к. м. н., доцент кафедры клинической фармакологии и интенсивной терапии, Волгоградский государственный медицинский университет, e-mail: mbfdoc@gmail.com