UDK: 615.21:547.466.3

INFLUENCE OF ADAMANTANE 2-PYRROLIDONE DERIVATIVE ON PHYSICAL PERFORMANCE, PSYCHOEMOTIONAL AND COGNITIVE FUNCTIONS OF LABORATORY ANIMALS IN COMPARISON WITH BROMANTHANE

N.S. Kovalev1, D.A. Bakulin1, E.E. Abrosimova1, D.V. Kurkin1, V.E. Pustynnikov1, Yu.N. Klimochkin2, I.M. Tkachenko2, I.N. Tyurenkov1

1ФГБОУ ВО «Волгоградский государственный медицинский университет» Минздрава России; 2ФГБОУ ВО «Самарский государственный технический университет»

Abstract

The effect of a new adamantane derivative of 2-pyrrolidone on the physical performance of rats when swimming with a load (for 5 days) was studied. It has been shown that a course, 5-day administration of IE-1 at a dose of 23 mg/kg 60 min before the first swim, significantly increases the swimming duration, comparable to that of bromantane. In addition, after a 5-day swim, animals treated with IE-1 showed higher motor and exploratory activity in the Open Field test, a lower level of anxiety in the Light/Dark Box test, and better indicators of cognitive function in the novel object recognition test.

Keywords

bromantane, physical performance, swimming with a load, adamantane, actoprotective action.

Contacts

Бакулин Дмитрий Александрович – к. м. н., доцент кафедры клинической фармакологии и интенсивной терапии, Волгоградский государственный медицинский университет, e-mail: mbfdoc@gmail.com