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V.A. Lazarenko, E.A. Bobrovskaya, A.A. Petrova
ФГБОУ ВО «Курский государственный медицинский университет» Министерства здравоохранения Российской Федерации, г. Курск кафедра хирург
The features of endothelial functional activity in patients with obliterating atherosclerosis with lesions of the femoral-popliteal (n = 140) and aorto-femoral (n = 97) segments before and after reconstructive interventions were studied. Endothelial status was assessed in systemic and local blood flow. There were no differences depending on the level of lesion in the content of homocysteine and the adhesive form of endothelial dysfunction. In the case of proximal lesions observed significantly high levels in systemic and local blood flow oxidized LDL and annexin V, and PAI-1 in systemic blood, with the distal – lower t-PA in the system (of 15,8 %, p = 0,013) and local (32,6 %, p = 0,0005) the bloodstream). There was an increase in prothrombotic potential during distal arterial reconstructions in the systemic blood flow (7,7 %, p = 0,009) and revascularized segment (26,5 %, p < 0,001) and an increase in apoptosis in the operated limb (17,6 %, p = 0,03) compared to proximal reconstructions.
arteriosclerosis obliterans, aorto-femoral bypass, femoral-popliteal bypass, endothelial dysfunction.
Бобровская Елена Анатольевна – д. м. н., доцент, доцент кафедры хирургических болезней ФПО, Курский государственный медицинский университет, e-mail: ea-bobrovskaya@yandex.ru