UDK: 576.851.132:616.982:27-039:576.8.09.2

ANTIGENS OF BURKHOLDERIA PSEUDOMALLEI AND BURKHOLDERIA MALLEI CONTAINING CARBOHYDRATES AS A POTENTIAL BASIS FOR DIAGNOSTIC AND PREVENTIVE MEASURES OF MELIOIDOSIS AND GLANDERS

I. I. Korsakova, N. N. Piven, N. P. Khrapova, S. I. Zhukova, I. V. Avrorova, M. Ya. Kulakov, L. V. Lomova, G. M. Napalkova, V. A. Sidoruk, N. A. Chuprina

Волгоградский научно-исследовательский противочумный институт

Abstract

Antigenic complexes of B.pseudomallei and B.mallei containing carbohydrates were isolated and characterized. They are included in the surface structures of outer membrane of these microbial agents. Immunogenicity of several antigens was studied. When administered to white rats the antigenic fractions of B.pseudomal-lei and of B.mallei protected 83—66 % of animals from the infection by B.pseudo-mallei virulent strain. These fractions together with antigens Ag 2, Ag 3, Ag 6, Ag 8 and Ag d of B.pseudomallei and major antigens of B.pseudomallei acapsular variants are considered as potential subunits for the creation of chemical vaccine as well as a tool for immunodiagnostics of melioidosis and glanders.

Keywords

antigenic complexes, B.pseudomallei, B.mallei, chemical vaccine, melioidosis, glanders.

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