UDK: 615:547.466.3:616.36+576.311.347
G.H. Khusainova, T.A. Popova, M.V. Kustova, O.V. Ostrovsky
Волгоградский государственный медицинский университет, Волгоград, Россия
The aim of the study was to study the effect of GABA derivatives on the functional activity of intact and oxidative stress-damaged mitochondria. Isolated mitochondria were obtained by differential centrifugation. Oxidative damage was simulated by incubation with tert-Butylhydroperoxide (200 nmol/ml, 10 min). The studied substances (baclofen, mefebut, neuroglutam, RGPU-238 compound, salifen, tolibut, phenibut, phenotropil) were added to intact and damaged mitochondria (1×10-5 M per 100 μl, 10 min of incubation), the functional state of mitochondria was studied using a polarographic method. It was revealed that salifen and phenotropil had a pronounced protective effect on the respiratory complexes of the electron transport chain.
GABA derivatives, glutamic acid derivatives, reactive oxygen species, mitochondrial respiration
Гульнара Хамзаевна Хусаинова, Gulnarahusainova130@gmail.com