Journal of VolgSMU
Quarterly scientific-practical journal

UDK: 615.281.014.47:547-304.2-32:547.458.8

STUDY OF INTERACTION OF ISONIAZID AND RIFAMPICIN WITH SOME HIGH-MOLECULAR COMPOUNDS

L. P. Ovcharenko, E. V. Kompantseva, G. G. Izrailova

Пятигорская государственная фармацевтическая академия

Abstract

On the basis of results of research of dynamics of change of relative viscosity of water solutions o f some highmolecular compounds with izoniazid and rifampicin we substantiated a possibility of using a method of viscosimetry for forecasting of bioavailability of medicinal substances. The expediency of using pectin, MS, NaKMS as optimum fillers for development of solid combined medicinal products izoniazid and rifampicin is shown.

Keywords

research of interaction of polymers and medicinal substances, izoniazid, rifampicin, viscosimetry, biopharmaceutical properties of medicinal substances

Contacts

Овчаренко Людмила Петровна — кандидат фармацевтических наук, докторант кафедры фармацевтической химии Пятигорской государственной фармацевтической академии, e-mail: nio@helios.ru