UDK: 616-002 — 008.953-092
L. V. Vokhmintseva, S. S. Rymar
Новосибирский государственный медицинский университет
To study the effect of experimental hypothyroidism on oxygen-related neutrophils biocidity in a rat model of acute gingival trauma we investigated the spontaneous and stimulated nitroblue tetrazolium test. Hypothyroid state in rat was induced by administration of 25 mg/kg mercazolyl for 21 days. Inflammation in rats with acute gingival trauma and hypothyroidism leads to a reduction in spontaneous and stimulated nitroblue tetrazolium test, diminished levels of malondialdehyde and glutathione in gingival tissue, a decrease in serum malondialdehyde level and in hemolysate glutathione level.
parodontal inflammation, hypothyroidism, nitroblue tetrazolium test
Вохминцева Лариса Вениаминовна — к.м.н., доцент кафедры биологической химии Новосибирского государственного медицинского университета, e-mail: vokhmintseva@yandex.ru