UDK: 616.155.1-092:616.931.452

ROLE OF LIPOPEROXIDATION ACTIVATION IN PATHOGENESIS OF EXPERIMENTAL PLAGUE INTOXICATION

G. A. Afanaseva, N. P. Chesnokova

Саратовский государственный медицинский университет

Abstract

Activation of lipid peroxidation increasing during elevation of clinical symptoms of Y. pestis intoxication and hypoxic syndrome development, is the efferent link in cytopathogenic effects of toxic and enzymatic factors of this microorganism. Absolute or relative insufficiency of enzymatic mechanisms of blood antioxidant protection systems is the main pathogenetic factor in lipid components of biomembrane destruction leading to the haemorrhagic syndrome development in Y. pestis intoxication.

Keywords

lipid peroxidation, Y. pestis intoxication

Contacts

Афанасьева Галина Александровна — к. м. н., доцент кафедры патологической физиологии Саратовского государственного медицинского университета, e-mail: gafanaseva@yandex.ru