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P. V. Glybochko, A. A. Svistunov, D. A. Morozov, O. L. Morozova, B. V. Dolgov, F. K. Napolnikov, A. V. Fisun, A. V. Maksimova
Саратовский государственный медицинский университет им. В. И. Разумовского
Results of blood and urine cytokines (IL-1betta, 6, 8, the FNO-alpha, 4,10) study in 40 children with vesicoureteral reflux in perioperative period are described in this article. It is revealed that even in the latent phase of chronic obstructive pyelonephritis there are expressed changes of cytokines profile in urine. It is shown that a change in the level of proinflammatory IL 8 and 6 is of the greatest prognostic value, which has a strong positive correlation with severity of inflammatory process in urinary tracts. We assume that a study of urine cytokines profile provides a noninvasive method for estimation of the severity of inflammatory process in urinary tracts, efficiency of administered conservative therapy, as well as a correction in the terms of carrying out operative interventions, which is especially important in young children.
cytokines, vesicoureteral reflux, children
Морозова Ольга Леонидовна — к. м. н., доцент кафедры патофизиологии, старший научный сотрудник НИИ уронефрологии Саратовского государственного медицинского университета, e-mail: morozova_ol@list.ru