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Optimization of therapy of microangiopathy at patients with a diabetes mellitus type II with using of a dipyridamole

Sobolevskaya N.V., Spasov A.A., Petraevsky A.V., Apukhtin A.F., Statsenko M.E.

Кафедра внутренних болезней педиатрического и стоматологического факультетов, кафедра фармакологии, кафедра офтальмологии, кафедра факультетской терапии ВолГМУ, КБ №3 ФГУ "ЮОМЦ Росздрава"

Abstract

The aim of research was to compare efficacy of complex therapy diabetic microangiopathy to using dipyridamole with standard therapy. 65 patients, 40- 65 years, with diabetes mellitus type II with an arterial hypertension and presence of microangiopathy were enrolled in the study. All patients received basic therapy with oral antidiabetes drugs in a combination to an angiotensin converting enzyme (ACE) inhibitor. In experienced group to main therapy was added dipyridamole on 75 mg 3 times a day. For an evaluation of efficacy of therapy researched rheological parameters of a blood, changes on an eyeground, function of kidney, parameters of oxygenous exchange in a skin. The obtained data testify, that the using dipyridamole in complex therapy diabetes mellitus type II such as at initial exhibitings microangiopathy allows to slow down development of microvascular complications.

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Contacts

Спасов Александр Алексеевич – ЗДН, член-корр. РАМН, д.м.н., профессор, зав. кафедрой фармакологии ВолГМУ, aaspasov@volgmed.ru, farm@vlpost.ru